Dr. Ravindra Kumar M. Sc., Ph.D.

Scientist D

ICMR-National Institute of Research in Tribal Health

Profile

Dr Ravindra Kumar has expertise in human genetic disorders especially hemoglobinopathies. He is currently contributing to the National Sickle Cell Anemia Elimination Mission.

Research Interests

 

  • Genetics
  • Molecular Hematology
  • Hemoglobinopathies

Scientific Staff

  1. Sh. ANUP KUMAR VISHWAKARMA - TECHNICIAN (1)
  2. MS. MALA PRAJAPATI - TECHNICIAN-A
  3. Sh.PANKAJ DHEER -TECHNICAL ASSISTANT
  4. Ms PALAK JAIN -TECHNICIAN (1)

Past Research students

  • Co Supervised 8 MD Students and 6 DM Students.

Ongoing research projects

  • Establishment of Center of Excellence in SCD
  • Mission Program on Pediatric Rare Genetic Disorders

Current research collaborators

N/A

Past research collaborators

N/A

Research in news

N/A

Award/Recognition/Honours

  • Dhirendra Nath Das Best paper published award by Indian Society of hematology and blood transfusion presented at Hematocon 2015 conference at Bangalore 5th to 8th Nov 2015.
  • Young Scientist Award under DST-Fast Track Scheme Aug 2012.
  • Research Associate Award by Council of Scientific and Industrial Research (CSIR) March 2012.
  • Best oral presentation award in International Conference of Genomic and Biomedical Research organized by Human Genetic Center, Department of Zoology, Gujarat University in Jan 2009.
  • Lectureship Exam (LS-NET), conducted by Council of Scientific and Industrial Research (CSIR) and University Grant commission (UGC) in Dec 2007.
  • Graduate Aptitude Test in Engineering (GATE) in Jan 2007 conducted by Indian Institute of Technology.
  • Junior Research Fellowship Exam (JRF-NET), conducted by Council of Scientific and Industrial Research(CSIR) and University Grant commission (UGC) in June 2007 under UGC Scheme.
  • Junior Research Fellowship Exam (JRF-NET), conducted by Council of Scientific and Industrial Research(CSIR) and University Grant commission (UGC) in Dec 2006 under CSIR Scheme.

Workshop/Conference Organized

  • State Level SCD Conference Madhya Pradesh on 3 Jan 2024 jointly organized by NASCO and NHM Bhopal.
  • Symposium on Sickle Cell Disease in India on 22 and 23 Feb 2023
  • Conference on Holistic Management of Sickle Cell Disease on World Sickle Cell Day, 19 Jun 2022
  • Webinar on “Sickle Cell Disease: Global Perspective and Indian Scenario” on World Sickle Cell Day, 19 June 2021
  • Hands on Training program for pathologists and technician on “Screening and diagnosis of hemoglobinopathies”. March 2020 at ICMR-NIRTH, Jabalpur
  • Hands on Training program for pathologists and technician on “Screening and diagnosis of hemoglobinopathies”. August and September 2019 at ICMR-NIRTH, Jabalpur
  • Orientation Program for CMO/CMHO/BMO on Hemoglobinopathies, Diagnosis, Prevention and management. September 2018 at ICMR-NIRTH, Jabalpur
  • One Day Seminar on Organization and Ethics of Biomedical Research Publications on 1st Jun 2018 at ICMR-NIRTH, Jabalpur
  • One Day CME on Thalassemia on 8th May 2016 at Sri Aurobindo Medical College and Post Graduate Institute, Indore
  • One Day CME on Frontiers in Management of Thalassemia at Sri Aurobindo Medical College and Post Graduate Institute, Indore on 31st August 2014 with 2 CME credits by Madhya Pradesh Medical Council
  • Five-day hands-on workshop and symposium on advanced laboratory practice in Molecular and Forensic Medicine from 16th -20th 2013 at Sri Aurobindo Medical College and Post Graduate Institute, Indore

Academic contributions

Ph. D.: Nil

Masters dissertation: 6

Papers published: 111

Research Grants

S no. Title of Project Funding Agency Duration
1 Genetic Predisposition of Premature Ovarian failure SERB-DST Jul 2012 to July 2016
2 Evaluation of paper-based screening test for Sickle cell anemia. ICMR (Intramural) April 2018 to March 2019
3 Community-wide screening for Mtb DNA in sputum samples ICMR (Intramural) Jan 2020 to Dec 2020
4 Establishment of Center of Excellence in SCD NHM, Bhopal June 2022 to Dec 2023
5 To study the dynamics of sickling inside blood capillary mimicking microfluidics system to fabricate a portable point-of-care electronic device for the detection of sickle cell disease ICMR, New Delhi Jan 2022 to Dec 2025
6 Mission Program on Pediatric Rare Genetic Disorders DBT, New Delhi March 2022 to March 2027

Publications

Research Publications (Last 7 Years)

  • Sondhiya G, Manjunathachar HV, Singh P, Kumar R. Indian J Med Res. 2024; 159: 1-18. Unveiling the Burden of Scrub Typhus in Acute Febrile Illness Cases across India: A Systematic review and Meta-analysis. Impact Factor: 2.7
  • Gupta P, Kumar R. Nitric oxide: A potential etiological agent for vaso-occlusive crises in sickle cell disease. Nitric Oxide. 2024. S1089-8603(24)00017-X. doi: 10.1016/j.niox.2024.01.008. Epub ahead of print. PMID: 38316197. Impact Factor: 3.9
  • Patel D, Kumar R. Community health workers in India should be trained to offer genetic counseling for rare diseases. Nat Med. 2024. doi 10.1038/s41591-023-02748-z. Epub ahead of print. PMID: 38200260. Impact Factor: 82.9
  • Rao E, Chandraker SK, Singh MM, Kumar R. Global distribution of β-thalassemia mutations: An Update. Gene. 2023 Nov 23:148022. doi: 10.1016/j.gene.2023.148022. Epub ahead of print. PMID: 38007159.
  • Gupta P, Singh P, Das A, Kumar R. Determinants of tuberculosis: an example of high tuberculosis burden in the Saharia tribe. Front Public Health. 2023 Oct 18;11:1226980. doi: 10.3389/fpubh.2023.1226980. PMID: 37920577; PMCID: PMC10619692. Impact Factor: 5.2
  • Singh MPSS, Kumar R, Patel P, Uikey R, Mun A, Shanmugam R. Hemoglobinopathies Among Patients Referred to Single Centre in Central India: An Observational Study. Ind J Clin Biochem. 2023. https://doi.org/10.1007/s12291-023-01151-2. Impact Factor: 2.1
  • Narayan A, Shrivastava V, Kumar R. Excerpt of Symposium on Sickle Cell Disease in India. Current Science. 2023;125(7):715-7. Impact Factor: 1.169
  • Gupta P, Kumar R. GTP cyclohydroxylase1 (GCH1): Role in neurodegenerative diseases. Gene. 2023;888:147749. doi: 10.1016/j.gene.2023.147749. PMID: 37652170. Impact Factor: 3.5
  • Kumar R, Chandraker SK, Das A. Controlling Sickle Cell Disease: The need of the hour. Clinical Epidemiology and Global Health. 2023;21:101302. doi 10.1016/j.cegh.2023.101302. Impact Factor: 2.6
  • Srivastava S, Kumar R. Is hyperleptinemia associated with gallstone disease? A systematic review and meta-analysis. Indian J Gastroenterol. 2023;42(3):324-331. doi: 10.1007/s12664-022-01332-6. Impact Factor: 2.00
  • Shrivastava S, Kumar R, Khan S, Kavishwar A, Gupta A, Kaur H, Das M, Sharma R and Chakma T. Health profile of people living in the Gare Palma mining area of Tamnar block, Raigarh, Chhattisgarh, India. Front. Public Health. 2023;11:1010025. doi: 10.3389/fpubh.2023.1010025. Impact Factor: 6.461
  • Shrivastava S, Kumar R, Shandil N, Saha KB, Das A. Letter: A Pilot Health and Nutritional Assessment of Tribes Living in a High Altitude District of Himachal Pradesh, India. High Alt Med Biol. 2023 Mar;24(1):79-80. doi: 10.1089/ham.2022.0110. Epub 2022 Dec 13. PMID: 36516111. Impact Factor: 2.183
  • Chandraker SK, Kumar R. Biogenic biocompatible silver nanoparticles: a promising antibacterial agent. Biotechnol Genet Eng Rev. 2022 Aug 2:1-35. doi: 10.1080/02648725.2022.2106084. Epub ahead of print. PMID: 35915981. Impact Factor: 4.20
  • Kumar R, Rajasubramaniam S, Das A. Sickle cell disease in India: Prevention-driven social and public health implications. Clinical Epidemiology and Global Health. 2022;15: 101047. doi: 10.1016/j.cegh.2022.101047. Impact Factor: 2.6
  • Kumar R. Neglecting borderline HbA2 (3.2–3.9%) may impede the prevention program for thalassemia. Clinical Epidemiology and Global Health. 2022;13: 100964. doi: 10.1016/j.cegh.2022.100964. Impact Factor: 2.6
  • Dixit N, Shaw CK, Varshney GA, Kumar R, Saini PA, Verma P. Endocrinal Complications in Children and Adolescents with Thalassemia Major in Central India: An Observational Study. Indian J Pediatr. 2022;89(10):983-988. doi: 10.1007/s12098-021-03883-6. Epub 2021 Sep 4. PMID: 34480715. Impact Factor: 5.319
  • Mun A, Kumar R, Tiwari S, Uikey R, Thakur P, Mishra S, Chakma T, Shanmugam R. First Observation of Compound Heterozygosity for Hb S/Hb Lepore-Hollandia in India. Indian J Hematol Blood Transfus. 2022;38(1):187-190. doi: 10.1007/s12288-021-01475-0. Epub 2021 Jul 27. PMID: 34334973; PMCID: PMC8315253. Impact Factor: 0.900
  • Kumar R, Das A. The Potential of mHealth as a Game Changer for the Management of Sickle Cell Disease in India. JMIR Mhealth Uhealth. 2021 Apr 13;9(4):e25496. doi: 10.2196/25496. PMID: 33847598. Impact Factor: 4.31
  • Kumar R, Mishra S, Gwal A, Shanmugam R. Evaluation of Paper-Based Point of Care Screening Test for Sickle Cell Disease. Indian J Clin Biochem. 2022 Apr;37(2):185-191. doi: 10.1007/s12291-021-00962-5. Epub 2021 Feb 8. PMID: 35463103; PMCID: PMC8993980.
  • Kumar R, Yadav R, Mishra S, Singh MPSS, Gwal A, Bharti PK, Rajasubramaniam S. Krüppel-like factor 1 (KLF1) gene single nucleotide polymorphisms in sickle cell disease and its association with disease-related morbidities. Front Genet. 2021;12:734332. doi: 10.3389/fgene.2021.734332. eCollection 2021. Impact Factor: 4.11
  • Kumar R, Gwal A, Shanmugam R, Das A, Yadav R. A Case Report of a Successful Sickle Cell Crisis Management Using Hydroxyurea in Adolescents: A Single Centre Experience. Indian J Hematol Blood Transfus. 2021;37(1):177-180. doi: 10.1007/s12288-020-01357-5. Impact Factor: 0.900
  • Kumar R, Yadav R, Mishra S, Singh MPSS, Gwal A, Bharti PK, Rajasubramaniam S. Krüppel-like factor 1 (KLF1) gene single nucleotide polymorphisms in sickle cell disease and its association with disease-related morbidities. Ann Hematol. 2021 Jan;100(1):157-166. doi: 10.1007/s00277-020-04376-3. Epub 2020 Oct 1. PMID: 33092457; PMCID: PMC7795694.
  • Kumar R, Mishra S, Uikey RS, Gwal A, Mun A, Bharti PK, Shanmugam R. De Novo Heterozygous Hb G - Waimanalo (α64(E13)Asp>Asn, CTG>CCG; HBA1:c.193G>A) Variant in a sickle cell disease patient of Indian tribe. J Clin Pathol. 2021;74:336–338. doi: 10.1136/jclinpath-2020-206589. IF: 3.411
  • Manjunathachar HV, Barde PV, Raut CG, Tiwari P, Chouksey V, Gowda K, Kumar R, Das A. Determination of cut-off of diagnostic ELISA for Scrub typhus in endemic setup: Central India. J Vector Borne Dis. 2021 Jan-Mar;58(1):90-93. doi: 10.4103/0972-9062.316272. PMID: 34818869. IF: 1.688
  • Chourasia S, Kumar R, Singh MPSS, Vishwakarma C, Gupta AK, Shanmugam R. High Prevalence of Anemia and Inherited Hemoglobin Disorders in Tribal Populations of Madhya Pradesh State, India. Hemoglobin. 2020 Nov;44(6):391-396. doi: 10.1080/03630269.2020.1848859. PMID: 33222570. IF: 0.526
  • Manjunathachar HV, Singh KN, Chouksey V, Kumar R, Sharma RK, Barde PV. Prevalence of Torch infections and its associated poor outcome in high-risk pregnant women of central India: Time to think for prevention strategies. Indian J Med Microbiol. 2020;38:379-84. IF: 0.900
  • Kumar R, Singh MPSS, Mahapatra S, Chaurasia S, Tripathi MK, Oommen J, Bharti PK, Shanmugam R. Fine Mapping of Glucose 6 Phosphate Dehydrogenase (G6PD) Deficiency in a Rural Malaria Area of South West Odisha Using the Clinical, Hematological and Molecular Approach. Mediterr J Hematol Infect Dis. 2020 Mar 1;12(1):e2020015. doi: 10.4084/MJHID.2020.015. PMID: 32180910; PMCID: PMC7059741. IF: 1.586
  • Kumar R, Shanmugam R. Red Cell Indices in Screening of Thalassemia Trait During Antenatal Period. J Obstet Gynaecol India. 2020 Apr;70(2):179-180. doi: 10.1007/s13224-019-01262-y. Epub 2019 Aug 22. PMID: 32255960; PMCID: PMC7109241.
  • Kumar R, Patel P, Gwal A, Bharti PK, Colah R, Rajasubramaniam S. Clinico-Hematological Presentation of Rare Hemoglobin Variant (HB-O Indonesia) in 3 Families. Indian J Hematol Blood Transfus. 2019 Jul;35(3):596-598. doi: 10.1007/s12288-019-01125-6. Epub 2019 Apr 17. PMID: 31388286; PMCID: PMC6646446. IF: 1.615
  • Singh MM, Kumar R, Tewari S, Agarwal S. Association of GSTT1/GSTM1 and ApoE variants with left ventricular diastolic dysfunction in thalassemia major patients. Hematology. 2019;24(1):20-25. doi:10.1080/10245332.2018.1502397. IF: 1.315
  • Kumar R, Rajasubramaniam S. Hurdles in Thalassemia Management. NIRTH Update 2018; 3(1):2-3.
  • Tripathi P, Kumar R, Agarwal S. Spectrum and hematological profile of hereditary anemia in North Indians: SGPGI experience. Intractable Rare Dis Res. 2018 Nov;7(4):258-263. doi: 10.5582/irdr.2018.01093. PMID: 30560018; PMCID: PMC6290850.
  • Nema N, Verma S, Kumar R. Investigation of methylenetetrahydrofolate reductase C677T and factor V Leiden mutation as a genetic marker for retinal vein occlusion. Taiwan J Ophthalmol. 2018 Apr-Jun;8(2):99-103. doi: 10.4103/tjo.tjo_43_17. PMID: 30038889; PMCID: PMC6055313.
  • Singh MM, Kumar R, Tewari S, Agarwal S. No Association of Genetic Markers with Carotid Intimal Medial Thickness in β-Thalassemia Major Patients. J Pediatr Genet. 2018 Mar;7(1):19-22. doi: 10.1055/s-0037-1608796. Epub 2017 Dec 6. PMID: 29441217; PMCID: PMC5809161.
  • Rishi L, Bhandari M, Kumar R. Can bariatric surgery delay the need for knee replacement in morbidly obese osteoarthritis patients? J Minim Access Surg. 2018 Jan-Mar;14(1):13-17. doi: 10.4103/jmas.JMAS_129_16. PMID: 28695875; PMCID: PMC5749191. IF: 1.282