डॉ अपरूप दास एम.एससी., पीएच.डी.

वैज्ञानिक जी एवं निदेशक

आईसीएमआर-राष्ट्रीय जनजाति स्वास्थ्य अनुसंधान संस्थान

प्रोफ़ाइल

डॉ. अपरूप दास प्रशिक्षित जनसंख्या आनुवंशिकीविद् और आणविक विकासवादी जीवविज्ञानी हैं। उन्होंने जीनोमिक्स और डीएनए अनुक्रम विश्लेषण पर अपने व्यापक प्रशिक्षण और अनुभव को कार्यान्वित किया है, शुरूआत में ड्रोसोफिला और बाद में मलेरिया में; साथ ही उन्होंने भारत और अफ्रीका में मलेरिया महामारी विज्ञान को समझने के लिए इन आधुनिक जैविक तकनीकों को लागू किया है। भुवनेश्वर के उत्कल विश्वविद्यालय से जूलॉजी (प्राणि विज्ञान) में स्नातक और स्नातकोत्तर उपाधि प्राप्त करने और बनारस हिंदू विश्वविद्यालय, वाराणसी से डॉक्टरेट की उपाधि प्राप्त के करने पश्चात डॉ. दास जर्मनी के म्यूनिख स्थित लुडविग मैक्सिमिलियन विश्वविद्यालय में चार वर्षीय पोस्ट-डॉक्टरेट अध्ययन के लिए गए, जहाँ उन्होंने जीनोमिक्स और जैव सूचना विज्ञान में प्रशिक्षण प्राप्त किया। वर्ष 2005 में भारत वापस आने के बाद, नई दिल्ली में आईसीएमआर-राष्ट्रीय मलेरिया अनुसंधान संस्थान, नई दिल्ली में वह एक वैज्ञानिक के रूप में शामिल हुए, जहाँ उन्होंने 12 वर्ष तक मलेरिया की आणविक महामारी विज्ञान का अध्ययन करके सेवा की। मई 2016 में, उन्होंने आईसीएमआर-चिकित्सा कीट विज्ञान अनुसंधान केंद्र, मदुरै, तमिलनाडु में निदेशक के रूप में कार्यभार ग्रहण किया और उसके बाद आईसीएमआर-राष्ट्रीय जनजाति स्वास्थ्य अनुसंधान संस्थान के निदेशक के रूप में यहां स्थानांतरित हुए। भारत और कैमरून (अफ्रीका) में मलेरिया की आणविक महामारी विज्ञान (मौलेक्यूलर ऐपिडेमायोलॉजी) पर उनके अनुसंधान के 14 वर्ष की अवधि में डॉ. दास और उनके अनुसंधान समूह ने मलेरिया परजीवी, दवा प्रतिरोध, मिश्रित प्रजातियों के संक्रमण, मच्छर वैक्टर की जनसंख्या की गतिशीलता, मलेरिया होने की संवेदनशीलता और मलेरिया से संबंधित फार्माकोजेनोमिक्स की कई दिलचस्प आनुवंशिक विशेषताओं को उजागर किया।

शोध के विषय

  • Genomic epidemiology of malaria and other Vector Borne Diseases
  • Transcriptomics and metabolonomic studies on malaria parasite
  • Translating the traditional tribal herbal knowledge to biomedical therapeutics for various ailments
  • Computer-Aided Drug Design of novel therapeutics for malaria and other Vector Borne Diseases

    • वैज्ञानिक कर्मचारी

  • Dr. Hiasindh Ashmi, ICMR centenary post-doctoral fellow
  • Ms. Upasana Singh, Research Assistant
  • Ms. Shristi Garg, Research Assistant

    • विगत शोध छात्र

    NA

    जारी अनुसंधान परियोजनाएं

  • Indo-Canadian (IC-IMPACTS) funded research project on point-of-care assay for malaria diagnosis and drug-resistance genotyping
  • NIH funded project on Centre for Study on the Complex malaria in India (CSCMi)
  • ICMR funded research project on Plasmodium vivax genomics under the Medical Innovation Fund scheme.
  • DST funded research project on P. falciparum proteomics.

    • वर्तमान अनुसंधान सहयोगी

  • Prof. Jane Carlton, New York University, USA
  • Dr. Stephanie Yanow, University of Alberta, Canada
  • Dr. Catherine Walton, University of Manchester, UK
  • Dr. Pragyan Acharya, AIIMS, New Delhi

    • विगत अनुसंधान सहयोगी

    NA

    समाचार में शोध

  • http://www.vigyanprasar.gov.in/isw/mixed_malaria_infections_story.html
  • http://www.downtoearth.org.in/news/severe-and-mixed-malaria-infections-posing-new-challenges-60221
  • https://www.biovoicenews.com/increase-in-deadly-malaria-infections-posing-new-challenges/
  • https://biotechtimes.org/2018/04/17/severe-mixed-malaria-infections-posing-new-challenges/
  • https://www.researchstash.com/2018/04/17/severe-and-mixed-malaria-infections-posing-new-challenges/
  • https://www.firstpost.com/tech/news-analysis/study-confirms-drastic-shift-in-malaria-occurrence-in-india-as-number-of-severe-cases-rise-4435677.html

    • पुरस्कार / मान्यता / सम्मान

  • Young scientists award from DST, Government of India
  • Overseas Associateship from DBT, Government of India
  • Postdoctoral Associateship from German Research Foundation

    • संगठित कार्यशाला / सम्मेलन

  • Global Exchange Lecture Course (15 days) funded by EMBO, Germany in 2010
  • Training course of genomics and bioinformatics of malaria (15 days) funded by DBT: 2012
  • Global Exchange Lecture Course (15 days), funded by EMBO, Germany in 2017

    • शैक्षणिक योगदान

  • Supervisor of Ph. D. thesis: 12
  • Masters dissertation: 62
  • Papers published: 100 plus

    • अनुसंधान अनुदान

  • Indo-French Centre for Promotion of Advanced Scientific Research (IFCPAR)
  • DST, Government of India
  • DBT, Government of India
  • CSIR, Government of India
  • ICMR, Government of India
  • EMBO, Germany
  • NIH, USA
  • German Science Foundation, Germany

    • प्रकाशन

    Ten best Publications on malaria:

    1. Rituraj Niranjan, Nishant Saxena, Aparup Das. Dengue control, if not by vaccination and vector strategies, then possibly by therapeutics. The Lancet Infectious Diseases. CORCH 2024. DOI: 10.1016/S1473-3099(23)00782-X.
    2. Carlton J, Das A, Escalante AA (2018) The evolution, genomic diversity, and epidemiological landscape of the complex malaria parasite Plasmodium vivax. Nature Reviews Microbiology: Invited Review.
    3. Siwal N, Singh US, Dash M, Kar S, Rani S, Rawal C, Singh RK, Anvikar AR, Pande V, Das A (2018) Malaria diagnosis by PCR revealed differential distribution of mono and mixed species infections by Plasmodium falciparum and P. vivax in India. PLoS ONE: 13: e0193046. View
    4. Singh US, Siwal N, Pande V, Das A (2017) Can mixed parasite infections thwart targeted malaria elimination program in India? BioMed Research International: 1-11. View
    5. Ngassa Mbenda HG, Das A (2016) Analysis of genetic diversity in the chloroquine-resistant gene Pfcrt in field Plasmodium falciparum isolates from five regions of the southern Cameroon. Infection Genetics and Evolution 44: 450-458. View
    6. Tyagi S, Das A (2015) Mitochondrial population genomic analyses reveal population structure and demography of Indian Plasmodium falciparum. Mitochondrion: 24: 9-21. View
    7. Das A (2015) The distinctive features of Indian malaria parasites. Trends in Parasitology: 31: 83-86. View
    8. Dixit J, Arunyawat U, Huong NT, Das A (2014) Multilocus nuclear DNA markers reveal population structure and demography of Anopheles minimus. Molecular Ecology: 23: 1599-1618. View
    9. Sharma M, Mohanty S, Tyagi S, Das A (2010) Comparative and evolutionary genomics of malaria parasites. Proceedings of National Academy of Sciences (Ind): 79: 111-121. View
    10. Singh V, Mishra N, Awasthi G, Dash AP, Das A (2009) Why is it important to study malaria epidemiology in India? Trends in Parasitology: 25: 452-457. View
    11. Das A, Dash AP (2007) Evolutionary paradigm of drug-resistant malaria in India. Trends in Parasitology: 23: 132-135. View


    Ten best publications on Drosophila:

    1. Schug MD, Baines JF, Killon-Atwood A, Mohanty S, Das A, Grath S, Smith SG, Zargham S, McEvey SF, Stephan W (2008) Evolution of mating isolation between populations of Drosophila ananassae. Molecular Ecology: 17: 2706-2721. View
    2. Das A, Mohanty S, Stephan W (2004) Inferring Population structure and demography of Drosophila ananassae from multilocus data. Genetics: 168: 1975-1985. View
    3. Baines JF, Das A, Mousset S, Stephan W (2004) The role of natural selection in genetic differentiation of worldwide populations of Drosophila ananassae. Genetics: 168: 1987-1998. View
    4. Vogl C, Das A, Beaumont M, Mohanty S, Stephan W (2003) Population subdivision and molecular sequence variation: Theory and analysis of Drosophila ananassae data. Genetics: 165: 1385-1395. View
    5. Baines JF, Chen Y, Das A, Stephan W (2002) DNA sequence variation at a gene of relatively recent origin: Excess of replacement polymorphism and extensive haplotype structure in the Drosophila melanogaster bicoid gene. Molecular Biology and Evolution: 19: 989-998. View
    6. Das A, Mohanty S, Capy P, David JR (1995) Mating propensity of Indian Drosophila melanogaster populations with Drosophila simulans: A non-adaptive latitudinal cline. Heredity: 74: 562-566. View
    7. Das A, Mohanty S, Parida BB (1994) Inversion polymorphism and extra bristles in Indian natural populations of Drosophila ananassae: joint variation. Heredity: 73: 405-409. View
    8. Singh BN, Das A (1992) Further evidence for latitudinal inversion clines in Indian natural populations of Drosophila melanogaster. Journal of Heredity: 83: 227-230. View
    9. Das A, Singh BN (1991) Genetic differentiation and inversion clines in Indian natural populations of Drosophila melanogaster. Genome: 34: 618-625. View
    10. Singh BN, Das A (1990) Inversion polymorphism in Indian natural populations of Drosophila melanogaster. Genome: 33: 311-316. View

    Research Publications (Last 7 Years)

    • Nambison NKM, Dwivedi AD, Kumar S, Goel G, Prasad P, Singh G, Rajasubramaniam S, Kumar R. Population-based Research in AYUSH: Lessons from Study among Particularly Vulnerable Tribal Groups to Determine Burden of Sickle Cell Disorders. Journal of Applied Sciences and Clinical Practice. 2024;5(3):138-144.
    • Seth T, Udupi S, Jain S, Bhatwadekar S, Menon N, Jena RK, Kumar R, Ray S, Parmar B, Goel AK, Vasava A, Dutta A, Samal P, Ballikar R, Bhat D, Dolai TK, Bhattacharyya J, Shetty D, Mistry M, Jain D. Burden of vaso-occlusive crisis, its management and impact on quality of life of Indian sickle cell disease patients. Br J Haematol. 2024 Oct 28. doi: 10.1111/bjh.19829. Epub ahead of print. PMID: 39463175. IF: 5.2
    • Gupta P, Kumar R. Targeting ICAM1 to Ameliorate Vaso-Occlusion and Inflammation in Sickle Cell Disease. Eur J Haematol. 2024 Oct 1. doi: 10.1111/ejh.14313. Epub ahead of print. PMID: 39354752. IF: 2.3
    • Rao E, Patel D, Saxena N, Saha KB, Kumar R. Ameliorating Mental Health Issues in Sickle Cell Disease Patients: A Viewpoint. Hemoglobin. 2024;48(3):212-213. doi: 10.1080/03630269.2024.2356607. Epub 2024 Sep 27. PMID: 39329378. IF: 1.2
    • Sondhiya G, Manjunathachar HV, Singh P, Kumar R. Unveiling the Burden of Scrub Typhus in Acute Febrile Illness Cases across India: A Systematic review and Meta-analysis. Indian J Med Res. 2024;159(6):601-618. doi: 10.25259/ijmr_1442_23. IF: 2.7
    • Gupta P, Choudhari V, Kumar R. Exploring the genetic mechanisms: SELP gene's contribution to alleviating vaso-occlusive crisis in sickle cell disease. Gene. 2024;928:148805. doi: 10.1016/j.gene.2024.148805. Epub ahead of print. PMID: 39079562. IF: 2.6
    • Gupta P, Kumar R. Nitric oxide: A potential etiological agent for vaso-occlusive crises in sickle cell disease. Nitric Oxide. 2024. S1089-8603(24)00017-X. doi: 10.1016/j.niox.2024.01.008. Epub ahead of print. PMID: 38316197. IF: 3.9
    • Patel D, Kumar R. Community health workers in India should be trained to offer genetic counseling for rare diseases. Nat Med. 2024. doi 10.1038/s41591-023-02748-z. Epub ahead of print. PMID: 38200260. IF: 82.9
    • Rao E, Chandraker SK, Singh MM, Kumar R. Global distribution of β-thalassemia mutations: An Update. Gene. 2023 Nov 23:148022. doi: 10.1016/j.gene.2023.148022. Epub ahead of print. PMID: 38007159.
    • Gupta P, Singh P, Das A, Kumar R. Determinants of tuberculosis: an example of high tuberculosis burden in the Saharia tribe. Front Public Health. 2023 Oct 18;11:1226980. doi: 10.3389/fpubh.2023.1226980. PMID: 37920577; PMCID: PMC10619692. IF: 5.2
    • Singh MPSS, Kumar R, Patel P, Uikey R, Mun A, Shanmugam R. Hemoglobinopathies Among Patients Referred to Single Centre in Central India: An Observational Study. Ind J Clin Biochem. 2023. https://doi.org/10.1007/s12291-023-01151-2. IF: 2.1
    • Narayan A, Shrivastava V, Kumar R. Excerpt of Symposium on Sickle Cell Disease in India. Current Science. 2023;125(7):715-7. IF: 1.169
    • Gupta P, Kumar R. GTP cyclohydroxylase1 (GCH1): Role in neurodegenerative diseases. Gene. 2023;888:147749. doi: 10.1016/j.gene.2023.147749. PMID: 37652170. IF: 3.5
    • Kumar R, Chandraker SK, Das A. Controlling Sickle Cell Disease: The need of the hour. Clinical Epidemiology and Global Health. 2023;21:101302. doi 10.1016/j.cegh.2023.101302. IF: 2.6
    • Srivastava S, Kumar R. Is hyperleptinemia associated with gallstone disease? A systematic review and meta-analysis. Indian J Gastroenterol. 2023;42(3):324-331. doi: 10.1007/s12664-022-01332-6. IF: 2.00